A Hundred-Year Researching History on the Low Ionic Strength in Red Blood Cells: Literature Review

This review article provides a critical survey of work from 1904 to 2003 on the effects low ionic strength in Red Blood Cells (RBCs) incubated media with impermeable sugars such as sucrose. In Gürber A washed RBCs different species isotonic sucrose solution eliminate outside ions order better analyse their intracellular composition; however, this approach was not feasible because substantial salt efflux cells. prominent feature loss is shrinking RBCs. central role understanding movements thereby new Donnan equilibrium anions. Experimental evidence has been given by Jacobs MH and Parpart AK 1933. medium two phases could be predicted: 1) very rapid anionic shift resulting an unequal distribution chloride hydroxyl anions both sides membrane 2) leakage salts 1940 Wilbrandt W assumed that positive potential line at 1977 Knauf PA, Fuhrmann GF, Rothstein S observed inhibition both, anion exchange also net efflux, incubation disulfonic stilbene derivates. At immediately obtained Anion Exchanger Protein (AEP). The opens least types cation pores or channels. Thereby conductivity pathway for anions, namely AEP, charge strength. AEP extensively blocked compounds. permeability ways cations through these channels are yet explored.